PoplarV1, Main, Exploration, bibRecord, 002943

Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.

Identifieur interne : 002943 ( Main/Exploration ); précédent : 002942; suivant : 002944

Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.

Auteurs : Despina Harbilas [Canada] ; Antoine Brault ; Diane Vallerand ; Louis C. Martineau ; Ammar Saleem ; John T. Arnason ; Lina Musallam ; Pierre S. Haddad

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2012.

RBID : pubmed:22504062

Descripteurs français

KwdFr :
- Agents antiobésité (pharmacologie), Agents antiobésité (usage thérapeutique), Alimentation riche en graisse (MeSH), Animaux (MeSH), Extraits de plantes (pharmacologie), Extraits de plantes (usage thérapeutique), Foie (effets des médicaments et des substances chimiques), Foie (métabolisme), Hypoglycémiants (pharmacologie), Hypoglycémiants (usage thérapeutique), Insulinorésistance (MeSH), Mitogen-Activated Protein Kinase 1 (métabolisme), Mitogen-Activated Protein Kinase 3 (métabolisme), Modèles animaux de maladie humaine (MeSH), Mâle (MeSH), Obésité (métabolisme), Obésité (traitement médicamenteux), Populus (MeSH), Souris (MeSH), Souris de lignée C57BL (MeSH), Température cutanée (MeSH), Tissu adipeux (effets des médicaments et des substances chimiques), Tissu adipeux (métabolisme), Triglycéride (métabolisme).
MESH :
- effets des médicaments et des substances chimiques : Foie, Tissu adipeux.
- métabolisme : Foie, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Obésité, Tissu adipeux, Triglycéride.
- pharmacologie : Agents antiobésité, Extraits de plantes, Hypoglycémiants.
- traitement médicamenteux : Obésité.
- usage thérapeutique : Agents antiobésité, Extraits de plantes, Hypoglycémiants.
- Alimentation riche en graisse, Animaux, Insulinorésistance, Modèles animaux de maladie humaine, Mâle, Populus, Souris, Souris de lignée C57BL, Température cutanée.

English descriptors

KwdEn :
- Adipose Tissue (drug effects), Adipose Tissue (metabolism), Animals (MeSH), Anti-Obesity Agents (pharmacology), Anti-Obesity Agents (therapeutic use), Diet, High-Fat (MeSH), Disease Models, Animal (MeSH), Hypoglycemic Agents (pharmacology), Hypoglycemic Agents (therapeutic use), Insulin Resistance (MeSH), Liver (drug effects), Liver (metabolism), Male (MeSH), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mitogen-Activated Protein Kinase 1 (metabolism), Mitogen-Activated Protein Kinase 3 (metabolism), Obesity (drug therapy), Obesity (metabolism), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Populus (MeSH), Skin Temperature (MeSH), Triglycerides (metabolism).
MESH :
- chemical , metabolism : Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Triglycerides.
- chemical , pharmacology : Anti-Obesity Agents, Hypoglycemic Agents, Plant Extracts.
- drug effects : Adipose Tissue, Liver.
- drug therapy : Obesity.
- metabolism : Adipose Tissue, Liver, Obesity.
- chemical , therapeutic use : Anti-Obesity Agents, Hypoglycemic Agents, Plant Extracts.
- Animals, Diet, High-Fat, Disease Models, Animal, Insulin Resistance, Male, Mice, Mice, Inbred C57BL, Populus, Skin Temperature.

Abstract

ETHNOBOTANICAL RELEVANCE

: In previous in vitro bioassay studies, Populus balsamifera L. (Salicaceae), a medicinal plant ethnobotanically identified from the traditional pharmacopoeia of the Cree of Eeyou Istchee (Eastern James Bay area of Canada), exhibited a strong anti-obesity potential by potently inhibiting adipogenesis in 3T3-L1 adipocytes. The aim of the study is to evaluate the effectiveness of this plant extract in mitigating the development of obesity and the metabolic syndrome in diet-induced obese (DIO) C57BL/6 mice.

MATERIALS AND METHODS

Mice were subjected for eight weeks to a standard diet (CHOW), a high fat diet (HFD; DIO group), or HFD to which Populus balsamifera was incorporated at 125 and 250 mg/kg.

RESULTS

The results showed that Populus balsamifera decreased in a dose-dependent manner the weight gain of whole body, retroperitoneal fat pad and liver as compared to DIO controls and reduced the severity of hepatic macrovesicular steatosis and triglyceride accumulation. This plant extract also decreased glycemia in the second half of the feeding period and improved insulin sensitivity by diminishing insulin levels and the leptin/adiponectin ratio, as well as augmenting adiponectin levels. These effects were associated with slightly but significantly reduced food intake with 250 mg/kg Populus balsamifera as well as with an increase in energy expenditure (increase in skin temperature and increased expression of uncoupling protein-1; UCP-1). Data also suggest other mechanisms, such as inhibition of adipocyte differentiation, decrease of hepatic inflammatory state and potential increase in hepatic fatty acid oxidation.

CONCLUSION

Taken together, these results confirm the potential of Populus balsamifera as a culturally adapted therapeutic approach for the care and treatment of obesity and diabetes among the Cree.

DOI: 10.1016/j.jep.2012.03.046
PubMed: 22504062

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 002A75
to stream Main, to step Curation: 002A75

Le document en format XML

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<term>Anti-Obesity Agents (pharmacology)</term>
<term>Anti-Obesity Agents (therapeutic use)</term>
<term>Diet, High-Fat (MeSH)</term>
<term>Disease Models, Animal (MeSH)</term>
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<term>Hypoglycemic Agents (therapeutic use)</term>
<term>Insulin Resistance (MeSH)</term>
<term>Liver (drug effects)</term>
<term>Liver (metabolism)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mitogen-Activated Protein Kinase 1 (metabolism)</term>
<term>Mitogen-Activated Protein Kinase 3 (metabolism)</term>
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<term>Obesity (metabolism)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant Extracts (therapeutic use)</term>
<term>Populus (MeSH)</term>
<term>Skin Temperature (MeSH)</term>
<term>Triglycerides (metabolism)</term>
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<term>Agents antiobésité (usage thérapeutique)</term>
<term>Alimentation riche en graisse (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Extraits de plantes (usage thérapeutique)</term>
<term>Foie (effets des médicaments et des substances chimiques)</term>
<term>Foie (métabolisme)</term>
<term>Hypoglycémiants (pharmacologie)</term>
<term>Hypoglycémiants (usage thérapeutique)</term>
<term>Insulinorésistance (MeSH)</term>
<term>Mitogen-Activated Protein Kinase 1 (métabolisme)</term>
<term>Mitogen-Activated Protein Kinase 3 (métabolisme)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Obésité (métabolisme)</term>
<term>Obésité (traitement médicamenteux)</term>
<term>Populus (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Température cutanée (MeSH)</term>
<term>Tissu adipeux (effets des médicaments et des substances chimiques)</term>
<term>Tissu adipeux (métabolisme)</term>
<term>Triglycéride (métabolisme)</term>
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<term>Hypoglycemic Agents</term>
<term>Plant Extracts</term>
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<term>Tissu adipeux</term>
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<term>Mitogen-Activated Protein Kinase 1</term>
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<term>Tissu adipeux</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiobésité</term>
<term>Extraits de plantes</term>
<term>Hypoglycémiants</term>
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<term>Diet, High-Fat</term>
<term>Disease Models, Animal</term>
<term>Insulin Resistance</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
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<term>Skin Temperature</term>
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<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p><b>ETHNOBOTANICAL RELEVANCE</b>
</p>
<p>: In previous in vitro bioassay studies, Populus balsamifera L. (Salicaceae), a medicinal plant ethnobotanically identified from the traditional pharmacopoeia of the Cree of Eeyou Istchee (Eastern James Bay area of Canada), exhibited a strong anti-obesity potential by potently inhibiting adipogenesis in 3T3-L1 adipocytes. The aim of the study is to evaluate the effectiveness of this plant extract in mitigating the development of obesity and the metabolic syndrome in diet-induced obese (DIO) C57BL/6 mice.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b>
</p>
<p>Mice were subjected for eight weeks to a standard diet (CHOW), a high fat diet (HFD; DIO group), or HFD to which Populus balsamifera was incorporated at 125 and 250 mg/kg.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The results showed that Populus balsamifera decreased in a dose-dependent manner the weight gain of whole body, retroperitoneal fat pad and liver as compared to DIO controls and reduced the severity of hepatic macrovesicular steatosis and triglyceride accumulation. This plant extract also decreased glycemia in the second half of the feeding period and improved insulin sensitivity by diminishing insulin levels and the leptin/adiponectin ratio, as well as augmenting adiponectin levels. These effects were associated with slightly but significantly reduced food intake with 250 mg/kg Populus balsamifera as well as with an increase in energy expenditure (increase in skin temperature and increased expression of uncoupling protein-1; UCP-1). Data also suggest other mechanisms, such as inhibition of adipocyte differentiation, decrease of hepatic inflammatory state and potential increase in hepatic fatty acid oxidation.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Taken together, these results confirm the potential of Populus balsamifera as a culturally adapted therapeutic approach for the care and treatment of obesity and diabetes among the Cree.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2012</Year>
<Month>09</Month>
<Day>28</Day>
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<Month>08</Month>
<Day>27</Day>
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<JournalIssue CitedMedium="Internet"><Volume>141</Volume>
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<PubDate><Year>2012</Year>
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<Title>Journal of ethnopharmacology</Title>
<ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation>
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<ArticleTitle>Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.</ArticleTitle>
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<Abstract><AbstractText Label="ETHNOBOTANICAL RELEVANCE" NlmCategory="UNASSIGNED">: In previous in vitro bioassay studies, Populus balsamifera L. (Salicaceae), a medicinal plant ethnobotanically identified from the traditional pharmacopoeia of the Cree of Eeyou Istchee (Eastern James Bay area of Canada), exhibited a strong anti-obesity potential by potently inhibiting adipogenesis in 3T3-L1 adipocytes. The aim of the study is to evaluate the effectiveness of this plant extract in mitigating the development of obesity and the metabolic syndrome in diet-induced obese (DIO) C57BL/6 mice.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Mice were subjected for eight weeks to a standard diet (CHOW), a high fat diet (HFD; DIO group), or HFD to which Populus balsamifera was incorporated at 125 and 250 mg/kg.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The results showed that Populus balsamifera decreased in a dose-dependent manner the weight gain of whole body, retroperitoneal fat pad and liver as compared to DIO controls and reduced the severity of hepatic macrovesicular steatosis and triglyceride accumulation. This plant extract also decreased glycemia in the second half of the feeding period and improved insulin sensitivity by diminishing insulin levels and the leptin/adiponectin ratio, as well as augmenting adiponectin levels. These effects were associated with slightly but significantly reduced food intake with 250 mg/kg Populus balsamifera as well as with an increase in energy expenditure (increase in skin temperature and increased expression of uncoupling protein-1; UCP-1). Data also suggest other mechanisms, such as inhibition of adipocyte differentiation, decrease of hepatic inflammatory state and potential increase in hepatic fatty acid oxidation.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Taken together, these results confirm the potential of Populus balsamifera as a culturally adapted therapeutic approach for the care and treatment of obesity and diabetes among the Cree.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harbilas</LastName>
<ForeName>Despina</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Canadian Institutes of Health Research Team in Aboriginal Antidiabetic Medicines, Department of Pharmacology, Université de Montréal, Montreal, QC, Canada.</Affiliation>
</AffiliationInfo>
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<MeshHeading><DescriptorName UI="D007333" MajorTopicYN="Y">Insulin Resistance</DescriptorName>
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<MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
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<MeshHeading><DescriptorName UI="D019950" MajorTopicYN="N">Mitogen-Activated Protein Kinase 1</DescriptorName>
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<MeshHeading><DescriptorName UI="D048052" MajorTopicYN="N">Mitogen-Activated Protein Kinase 3</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="Y">Populus</DescriptorName>
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<MeshHeading><DescriptorName UI="D012881" MajorTopicYN="N">Skin Temperature</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>01</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2012</Year>
<Month>03</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>03</Month>
<Day>28</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
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<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
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<PubMedPubDate PubStatus="medline"><Year>2012</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22504062</ArticleId>
<ArticleId IdType="pii">S0378-8741(12)00208-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.jep.2012.03.046</ArticleId>
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<affiliations><list><country><li>Canada</li>
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<tree><noCountry><name sortKey="Arnason, John T" sort="Arnason, John T" uniqKey="Arnason J" first="John T" last="Arnason">John T. Arnason</name>
<name sortKey="Brault, Antoine" sort="Brault, Antoine" uniqKey="Brault A" first="Antoine" last="Brault">Antoine Brault</name>
<name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S" last="Haddad">Pierre S. Haddad</name>
<name sortKey="Martineau, Louis C" sort="Martineau, Louis C" uniqKey="Martineau L" first="Louis C" last="Martineau">Louis C. Martineau</name>
<name sortKey="Musallam, Lina" sort="Musallam, Lina" uniqKey="Musallam L" first="Lina" last="Musallam">Lina Musallam</name>
<name sortKey="Saleem, Ammar" sort="Saleem, Ammar" uniqKey="Saleem A" first="Ammar" last="Saleem">Ammar Saleem</name>
<name sortKey="Vallerand, Diane" sort="Vallerand, Diane" uniqKey="Vallerand D" first="Diane" last="Vallerand">Diane Vallerand</name>
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<country name="Canada"><noRegion><name sortKey="Harbilas, Despina" sort="Harbilas, Despina" uniqKey="Harbilas D" first="Despina" last="Harbilas">Despina Harbilas</name>
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   |texte=   Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.
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Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.

Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.

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